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Inversin is a protein in humans that is encoded by INVS gene. Required for normal renal development and establishment of left-right axis. Probably acts as a molecular switch between different Wnt signaling pathways. Inhibits the canonical Wnt pathway by targeting cytoplasmic disheveled (DVL1) for degradation by the ubiquitin-proteasome. This suggests that it is required in renal development to oppose the repression of terminal differentiation of tubular epithelial cells by Wnt signaling. Involved in the organization of apical junctions in kidney cells together with NPHP1, NPHP4 and RPGRIP1L/NPHP8 (By similarity). Does not seem to be strictly required for ciliogenesis (By similarity).
The following INVS reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
INVS Antibodies for Homo sapiens (Human)
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA011769GA01HU | INVS Antibody |
Human,Mouse,Rat | ELISA,WB,IHC,IF |
| CSB-PA011769LA01HU | INVS Antibody |
Human | ELISA, WB, IHC, IF |
| CSB-PA011769LB01HU | INVS Antibody, HRP conjugated |
Human | ELISA |
| CSB-PA011769LC01HU | INVS Antibody, FITC conjugated |
Human | |
| CSB-PA011769LD01HU | INVS Antibody, Biotin conjugated |
Human | ELISA |
INVS Antibodies for Danio rerio (Zebrafish) (Brachydanio rerio)
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA011769XA01DIL | invs Antibody |
Danio rerio (Zebrafish) (Brachydanio rerio) | ELISA, WB (ensure identification of antigen) |
INVS Proteins for Mus musculus (Mouse)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP011769MO CSB-EP011769MO CSB-BP011769MO CSB-MP011769MO CSB-EP011769MO-B |
Recombinant Mouse Inversin (Invs), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
INVS Proteins for Canis lupus familiaris (Dog) (Canis familiaris)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP011769DO CSB-EP011769DO CSB-BP011769DO CSB-MP011769DO CSB-EP011769DO-B |
Recombinant Dog Inversin (INVS), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
INVS Proteins for Danio rerio (Zebrafish) (Brachydanio rerio)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP011769DIL CSB-EP011769DIL CSB-BP011769DIL CSB-MP011769DIL CSB-EP011769DIL-B |
Recombinant Danio rerio Inversin (invs), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
INVS Proteins for Gallus gallus (Chicken)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP011769CH CSB-EP011769CH CSB-BP011769CH CSB-MP011769CH CSB-EP011769CH-B |
Recombinant Chicken Inversin (INVS), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
INVS Proteins for Homo sapiens (Human)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP011769HU CSB-EP011769HU CSB-BP011769HU CSB-MP011769HU CSB-EP011769HU-B |
Recombinant Human Inversin (INVS), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
