Inversin is a protein in humans that is encoded by INVS gene. Required for normal renal development and establishment of left-right axis. Probably acts as a molecular switch between different Wnt signaling pathways. Inhibits the canonical Wnt pathway by targeting cytoplasmic disheveled (DVL1) for degradation by the ubiquitin-proteasome. This suggests that it is required in renal development to oppose the repression of terminal differentiation of tubular epithelial cells by Wnt signaling. Involved in the organization of apical junctions in kidney cells together with NPHP1, NPHP4 and RPGRIP1L/NPHP8 (By similarity). Does not seem to be strictly required for ciliogenesis (By similarity).

INVS Antibodies

INVS Antibodies for Homo sapiens (Human)

INVS Antibodies for Human

INVS Antibodies for Danio rerio (Zebrafish) (Brachydanio rerio)

INVS Proteins

INVS Proteins for Mus musculus (Mouse)

INVS Proteins for Canis lupus familiaris (Dog) (Canis familiaris)

INVS Proteins for Danio rerio (Zebrafish) (Brachydanio rerio)

INVS Proteins for Gallus gallus (Chicken)

INVS Proteins for Homo sapiens (Human)


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