IRGQ

IRGQ, Immunity-related GTPase family Q protein, alias IRGQ1, FKSG27. IRGQ is translocated to the lysosome in an autophagy-dependent manner through interactions with GABARAPL2 and LC3B, and mediates tumor immune escape by affecting the expression of MHC class I quality control as a key regulator of MHCI class I. IRGQ plays an important role in tumor immune escape, and its high expression is associated with low MHC class I gene expression and is associated with shorter patient survival time. IRGQ deficiency limits tumor growth by enhancing the expression of MHC class I molecules and subsequent CD8+ T-cell responses.
IRGQ is not only important in regulating immune responses, especially in tumor immune escape and anti-tumor immune responses, but also offers new perspectives on enhancing the efficacy of tumor immunotherapy through targeting IRGQ provides a new perspective.

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Recombinant Human Immunity-related GTPase family Q protein (IRGQ)