Integrin beta-7 is a protein in humans that is encoded by ITGB7 gene. Integrin alpha-4/beta-7 (Peyer patches-specific homing receptor LPAM-1) is an adhesion molecule that mediates lymphocyte migration and homing to gut-associated lymphoid tissue (GALT). Integrin alpha-4/beta-7 interacts with the cell surface adhesion molecules MADCAM1 which is normally expressed by the vascular endothelium of the gastrointestinal tract. Interacts also with VCAM1 and fibronectin, an extracellular matrix component. It recognizes one or more domains within the alternatively spliced CS-1 region of fibronectin. Interactions involves the tripeptide L-D-T in MADCAM1, and L-D-V in fibronectin. Binds to HIV-1 gp120, thereby allowing the virus to enter GALT, which is thought to be the major trigger of AIDS disease. Interaction would involve a tripeptide L-D-I in HIV-1 gp120. Integrin alpha-E/beta-7 (HML-1) is a receptor for E-cadherin.
The following ITGB7 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
ITGB7 Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA011891GA01HU | ITGB7 Antibody |
Human,Mouse,Rat | ELISA,WB,IHC |
CSB-PA939542 | ITGB7 Antibody |
Human | ELISA,WB,IHC |
CSB-PA588701 | ITGB7 Antibody |
Human | ELISA,IHC |
CSB-PA011891ESR1HU | ITGB7 Antibody |
Human | ELISA, WB, IHC |
CSB-PA011891ESR2HU | ITGB7 Antibody |
Human | ELISA, IHC |
ITGB7 Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-CF011891HU | Recombinant Human Integrin beta-7(ITGB7) |
in vitro E.coli expression system |
CSB-YP011891HU1 CSB-BP011891HU1 CSB-MP011891HU1 CSB-EP011891HU1-B |
Recombinant Human Integrin beta-7(ITGB7),partial |
Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-EP011891HU1 | Recombinant Human Integrin beta-7(ITGB7),partial |
E.coli |
ITGB7 Proteins for Mus musculus (Mouse)
Code | Product Name | Source |
---|---|---|
CSB-CF011891MO | Recombinant Mouse Integrin beta-7(Itgb7) |
in vitro E.coli expression system |
CSB-YP011891MO1 CSB-EP011891MO1 CSB-BP011891MO1 CSB-MP011891MO1 CSB-EP011891MO1-B |
Recombinant Mouse Integrin beta-7(Itgb7),partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ITGB7 ELISA Kit for Homo sapiens (Human)
Code | Product Name | Sample Types | Sensitivity |
---|---|---|---|
CSB-EL011891HU | Human Integrin beta-7(ITGB7) ELISA kit |
serum, plasma, tissue homogenates | 0.078 ng/mL |