KCNQ2

KCNQ2, a voltage-gated potassium channel, is expressed mainly in the nervous system.The KCNQ2 gene is located on human chromosome 20 and encodes a protein consisting of six transmembrane α-helical structural domains that form a potassium-selective channel.The mechanism of action of KCNQ2 is to regulate the flow of potassium ions by sensing the changes in cellular membrane potential, maintaining the resting cellular membrane potential, which is essential for nerve cell excitability and signalling. Biologically, KCNQ2 is involved in a variety of functions in the nervous system, including auditory signalling, cognitive functions, and cardiac autonomic rhythm regulation.Mutations in the KCNQ2 gene have been associated with certain hereditary deafness and cardiac disorders, such as Jervell and Lange-Nielsen syndromes, which are associated with a loss or alteration of the channel's function, emphasising the importance of KCNQ2 in the maintenance of normal physiological functions. importance in maintaining normal physiological function.

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Recombinant Human Potassium voltage-gated channel subfamily KQT member 2 (KCNQ2), partial

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