KCTD20

The protein encoded by the gene KCTD20, also known as potassium channel tetramerization domain containing 20, is a BTB/POZ domain-containing protein. It is predicted to enable identical protein binding activity and is involved in positive regulation of phosphorylation and signal transduction. KCTD20 interacts with AKT1, AKT2, and AKT3, and is associated with PP2CA. It is a positive regulator of Akt and may play a role in regulating the death and growth of some non-nervous and nervous cells. KCTD20 is also associated with diseases such as progressive myoclonus epilepsy and may be a target for drug research.
Recent research has highlighted the potential of KCTD20 as a therapeutic target. Studies have shown that KCTD20 suppression mitigates excitotoxicity in tauopathy patient organoids, suggesting its involvement in neurodegenerative diseases. Drug research progress includes the development of KCTD20-specific antibodies and potential gene therapies for diseases linked to KCTD20 dysfunction.