KDM2A

KDM2A is a demethylase enzyme that selectively erases dimethyl marks on histone H3 at lysine 36, while showing limited activity towards other methylation states of H3K36. Its function is influenced by microRNA and phosphorylation, which are key to its regulatory mechanisms. KDM2A is drawn to unmethylated CpG islands where it demethylates histone H3K36 residues and also engages with phosphorylated proteins, promoting their ubiquitination and degradation. This enzyme is central to chromosome restructuring and gene expression, thereby impacting cellular processes such as proliferation, differentiation, and metabolism, as well as the stability of chromosomes and genes. Importantly, KDM2A's role extends to cancer development, where its misregulated expression is associated with a variety of tumors.

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Recombinant Human Lysine-specific demethylase 2A (KDM2A), partial