KLHDC2

KLHDC2 Kelch domain-containing protein 2 is an E3 ubiquitin ligase with a Kelch domain, belonging to the Kelch protein superfamily. It can assemble into dynamic tetramers and regulate the binding of substrates and ligands through its C-terminal self-association. The function of KLHDC2 involves protein ubiquitination and protein degradation. As part of the Cul2-RINGCRL2E3 ubiquitin protein ligase complex, it participates in the DesCEND pathway, which promotes the degradation of specific proteins by recognizing their C-terminal degradation signals. In addition, KLHDC2 is involved in biological processes such as cell signaling, cell adhesion, and cell migration, and its expression level is closely related to the occurrence and development of various diseases, including tumors, diabetes, and neurological diseases. Therefore, KLHDC2 not only plays an important role in cell biology, but also has broad application prospects as a drug target or biomarker in the field of drug development. By targeting small molecule ligands of KLHDC2, new therapeutic methods can be developed, especially in the field of protein degradation therapy.