KMT5A

KMT5A, also known as SETD8, is the protein encoded by this gene. It's also commonly referred to as PR-SET7 or SET8. KMT5A is a lysine methyltransferase that specifically monomethylates histone H4 at lysine 20 (H4K20me1), playing crucial roles in DNA replication, cell cycle regulation, and chromatin organization. This protein is involved in the p53 signaling pathway.
Aberrant expression of KMT5A has been linked to various diseases, particularly cancers like breast and colon cancer. Currently, there is ongoing research to develop drugs targeting KMT5A. Inhibitors of this protein are being explored as potential anti - cancer therapies due to its key functions in tumorigenesis.