LBR

LBR, also known as lamin B receptor, is a nuclear envelope protein that plays a crucial role in nuclear shape and function. It interacts with the nuclear lamina and acts as a receptor for the small GTPase RhoA, regulating nuclear envelope dynamics. LBR is involved in various signaling pathways, including the RhoA/ROCK pathway, which controls cell migration and cytokinesis. Dysregulation of LBR has been associated with several diseases, such as Greenberg Dysplasia and Reynolds Syndrome. In drug development, targeting LBR may offer therapeutic benefits for these conditions. Research is ongoing to understand the full potential of LBR as a drug target.