MAGEA12

MAGEA12, also known as Melanoma-Associated Antigen A12, is a protein coding gene that plays a role in tumor transformation and progression. It is commonly expressed in melanoma, squamous cell carcinoma, and other malignancies. MAGEA12 functions by regulating cell survival, proliferation, and apoptosis. It interacts with various cellular proteins, including those involved in the ubiquitin-proteasome system and DNA repair processes. The protein is associated with several diseases, including melanoma, squamous cell carcinoma, and prostate cancer. In terms of drug development, MAGEA12 inhibitors are being investigated for their potential in targeted cancer therapy, particularly in melanoma and squamous cell carcinoma. These inhibitors disrupt the interaction between MAGEA12 and other proteins, leading to increased cell death and reduced tumor growth.