MYO1G

MYO1G, also known as myosin-1G, is a class I myosin motor protein expressed in hematopoietic cells. It plays a crucial role in cell migration, adhesion, and membrane trafficking. MYO1G interacts with actin filaments and the plasma membrane, regulating cellular functions such as endocytosis, exocytosis, and membrane tension. It is involved in various signaling pathways, including the FAK-PI3K-Rac1 pathway and the PLD2-mTORC2 pathway. MYO1G deficiency has been associated with impaired B cell migration and altered cell morphology, potentially contributing to diseases like acute lymphoblastic leukemia (ALL). Recent research has focused on the development of monoclonal antibodies against MYO1G for potential diagnostic and therapeutic applications in ALL.