PARP12

PARP12, also known as Poly [ADP-ribose] polymerase 12, is part of the PARP family. It has several aliases such as ARTD12. Its main mechanism involves adding ADP - ribose moieties to target proteins, which can regulate protein function and cellular processes. It is associated with the interferon - stimulated signaling pathway, playing a role in antiviral responses and innate immunity.
Dysregulation of PARP12 has been linked to various diseases, including certain viral infections and autoimmune disorders. In drug development, PARP12 is being explored as a potential therapeutic target. Some small - molecule inhibitors are under pre - clinical research to modulate its activity for better disease treatment.