PELI2

PELI2, a member of the pellino E3 ubiquitin protein ligase family and also known as Pellino-2, is an E3 ubiquitin ligase involved in protein ubiquitination. It functions by adding ubiquitin molecular tags to proteins, regulating their degradation and signal transduction. PELI2 contributes to cellular processes such as stress response, inflammation, and immune signaling. It acts as a negative regulator of the STING signaling pathway, inhibiting the STING-IRF3 signal axis to prevent activation by cytoplasmic dsDNA under basal conditions. However, during viral infections, PELI2 is down-regulated, activating STING signaling and creating a positive feedback loop. Additionally, PELI2's down-regulation in autoimmune diseases may trigger inflammatory responses and is associated with heightened sensitivity to dsDNA, potentially contributing to conditions like systemic lupus erythematosus.

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Recombinant Human E3 ubiquitin-protein ligase pellino homolog 2 (PELI2)