PTER

PTER, phosphotriesterase-related protein, alias HPHRP, RPR-1. it is an enzyme encoded by the human PTER gene and is expressed predominantly in the kidneys, liver, and brainstem.
The mechanism of action of PTER is through the catalytic hydrolysis of N-acetyltaurine to taurine and acetate, a process that plays a role in the regulation of eating behavior and obesity. PTER acts as a secondary taurine metabolism central enzyme node, is involved in weight control and regulation of energy balance by affecting N-acetyltaurine levels. Loss of PTER activity results in a complete loss of tissue N-acetyltaurine hydrolysis activity and a systematic elevation of N-acetyltaurine levels, leading to reduced food intake, resistance to diet-induced obesity, and improvement of glucose homeostasis.
PTER has an important role in the regulation of body weight, energy balance, and possibly the be biologically important in the treatment of metabolic diseases.

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Recombinant Human Phosphotriesterase-related protein (PTER)