PTGFRN

Prostaglandin F2 receptor negative regulator (PTGFRN), also known as CD315 or MAKORIN2, is a transmembrane protein that regulates cell adhesion and migration through interactions with integrins and other membrane proteins. It functions as a scaffolding molecule, stabilizing surface protein complexes and modulating intracellular trafficking pathways. PTGFRN participates in the integrin-mediated signaling network, influencing extracellular matrix remodeling and cell-matrix communication. Dysregulation of PTGFRN has been implicated in tumor progression, particularly in breast and colorectal cancers, where it promotes metastasis through enhanced cell motility. Emerging evidence links its overexpression to inflammatory disorders such as rheumatoid arthritis. Current therapeutic strategies targeting PTGFRN include monoclonal antibodies against its extracellular domain and small-molecule inhibitors disrupting protein-protein interactions, with several candidates demonstrating preclinical efficacy in suppressing cancer metastasis and inflammatory responses.