PTP4A3

PTP4A3, also known as Protein Tyrosine Phosphatase Type IVA 3, is commonly called PRL-3. This protein plays a significant role in cell proliferation, migration, and invasion. It functions through dephosphorylating specific substrates, thus modulating signal transduction. It is involved in pathways like PI3K/AKT, which are crucial for cell survival and growth.
PTP4A3 is strongly associated with various cancers, including colorectal, ovarian, and gastric cancers. High expression levels often indicate poor prognosis. In drug development, efforts are underway to design inhibitors targeting PTP4A3, aiming to disrupt its function and potentially halt cancer progression.