RAET1L

RAET1L, also known as Retinoic acid early transcript 1L, is a protein - coding gene. Its protein has few well - recognized aliases. The encoded protein is a ligand for NKG2D, an activating receptor on natural killer cells and T - cells. This interaction activates immune responses, playing a crucial role in immunosurveillance. It is involved in the NKG2D - mediated signaling pathway, which helps in detecting and eliminating infected or transformed cells.
In terms of related diseases, abnormal expression of RAET1L is associated with tumorigenesis, as tumors may use various mechanisms to down - regulate its expression to evade immune attack. Currently, there are ongoing research efforts in drug development, aiming to enhance the immune recognition of cancer cells by targeting the RAET1L - NKG2D axis, but significant clinical breakthroughs are yet to be achieved.