RAF1 Research Reagents

RAF proto-oncogene serine/threonine-protein kinase is a protein in humans that is encoded by RAF1 gene. Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinases (MAPK3/ERK1 and MAPK1/ERK2).

The following RAF1 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

RAF1 Antibodies

RAF1 Antibodies for Homo sapiens (Human)

RAF1 Antibodies for Rattus norvegicus (Rat)

RAF1 Antibodies for Zea mays (Maize)

RAF1 Antibodies for Oryza sativa subsp. japonica (Rice)

RAF1 Antibodies for Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

RAF1 Antibodies for Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)

RAF1 Proteins

RAF1 Proteins for Rattus norvegicus (Rat)

RAF1 Proteins for Homo sapiens (Human)

RAF1 Proteins for Gallus gallus (Chicken)

RAF1 Proteins for Bos taurus (Bovine)

RAF1 Proteins for Xenopus laevis (African clawed frog)

RAF1 Proteins for Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)

RAF1 Proteins for Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)

RAF1 Proteins for Mus musculus (Mouse)

RAF1 Background

RAF proto-oncogene serine/threonine-protein kinase is a protein in humans that is encoded by RAF1 gene [1][2]. RAF1 is part of a signaling pathway called the RAS/MAPK pathway, which transmits chemical signals from outside the cell to the cell's nucleus. RAS/MAPK signaling helps control the growth and division (proliferation) of cells, the process by which cells mature to carry out specific functions (differentiation), cell movement (migration), and the self-destruction of cells (apoptosis). As a serine/threonine-protein kinase, RAF1 acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinases (MAPK3/ERK1 and MAPK1/ERK2).

[1] Li P, Wood K, Mamon H, Haser W, Roberts T (February 1991). "Raf-1: a kinase currently without a cause but not lacking in effects". Cell. 64 (3): 479–82.
[2] Rapp UR, Goldsborough MD, Mark GE, Bonner TI, Groffen J, Reynolds FH, Stephenson JR (July 1983). "Structure and biological activity of v-raf, a unique oncogene transduced by a retrovirus". Proc. Natl. Acad. Sci. U.S.A. 80 (14): 4218–22.

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