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CUSABIO designed the vector clones for the expression of a recombinant RAF1 antibody in mammalian cells. The vector clones were obtained by inserting the RAF1 antibody heavy and light chains into the plasma vectors. The recombinant RAF1 antibody was purified from the culture medium through affinity-chromatography. It can be used to detect RAF1 protein from Human in the ELISA, WB, IF.
RAF1 is a kinase that acts as the effector associating RAS with MEK/ERK activation. It is involved in multiple cellular activities such as cell proliferation, differentiation, cell death and survival, metabolism, and motility. RAF1 is essential for the development of skin and lung tumors and can negatively regulate hepatocarcinogenesis. RAF1 is regulated by phosphorylation, and phosphorylation at the S621 enhances RAF1 kinase activity by providing a second, positive binding site for 14-3-3, which is required for RAF1 kinase activity.
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