RAPGEF3

RAPGEF3, also known as Rap guanine nucleotide exchange factor 3, is a protein that facilitates guanyl-nucleotide exchange factor activity and protein domain specific binding. It plays a crucial role in Rap protein signal transduction, cellular response to cAMP, and regulation of syncytium formation by plasma membrane fusion. RAPGEF3 is involved in various cellular processes, including cell adhesion, axon regeneration, and neurite extension. It is associated with neurological disorders, such as neuropathic pain, and has potential as a therapeutic target.
RAPGEF3 is a sensor of the cellular second messenger cAMP and acts as the exchange factor of the Rap and Ras families. It mediates cAMP signaling, which is essential for regulating numerous cellular processes, including proliferation, differentiation, and development. Research on RAPGEF3 has identified its involvement in diseases like neuropathic pain and cancer, and it has become a focus for drug development, particularly in targeting signaling pathways associated with these conditions.