RLN2

RLN2, also known as Relaxin 2, and by other names such as H2, REL2_HUMAN, Relaxin 2, Relaxin A chain, and Relaxin H2, is a peptide hormone that belongs to the insulin superfamily and is encoded by the RLN2 gene. In humans, there are three non-allelic relaxin genes that encode several protein isoforms, at least one of which undergoes proteolytic processing to produce Relaxin A and B chains, which are linked by disulfide bonds to form the mature peptide hormone. RLN2 plays a role in the reproductive system, particularly during pregnancy, and also in the cardiovascular system, including the regulation of blood pressure and control of heart rate. Data from animal models suggest that RLN2 may have anti-fibrotic and cardioprotective effects.

The mechanism of action for RLN2 involves binding to its receptor and activating signaling pathways, thereby exerting biological effects. RLN2 has a critical role in reproduction and pregnancy and is also important in regulating cardiovascular function, anti-inflammatory responses, and immunomodulation. Additionally, dysfunctions in RLN2 are associated with certain diseases, such as preterm labor, bone cancer, and ear diseases, making it a potential target for drug development and disease treatment.

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Recombinant Human Prorelaxin H2 (RLN2)