RPAP2

RPAP2, also known as RNA polymerase II associated protein 2, is a protein coding gene that plays a crucial role in gene expression and transcription. It functions as a CTD heptapeptide repeat phosphatase, regulating the activity of RNA polymerase II. RPAP2 is involved in PERK-mediated unfolded protein response and snRNA transcription, and is localized in the cytoplasm and nucleolus, contributing to the transcription preinitiation complex.
Recent research has linked RPAP2 to various diseases, including cholestasis and muscular degeneration. The protein's role in these conditions suggests potential therapeutic targets for drug development. Studies are ongoing to explore the signaling pathways affected by RPAP2 and to identify novel drugs that can modulate its activity for treating associated diseases.