SCN10A

SCN10A, encoded by the human SCN10A gene on chromosome 3, is a protein that forms voltage-gated sodium channels, crucial for the flow of sodium ions, particularly in pain signal transmission and cardiac electrophysiology. Expressed in nerve cells like the nociceptors of the dorsal root ganglia, SCN10A plays a role in pain signal transmission. It also has a potential role in cardiac rhythm regulation, with mutations linked to conditions such as Brugada syndrome. Abnormalities in SCN10A are associated with pain disorders and arrhythmias, making it a significant target for therapeutic interventions in these areas.