SCN8A

SCN8A, Sodium Voltage-Gated Channel Alpha Subunit 8. It is a protein expressed in neuronal cells and encoded by the SCN8A gene located on chromosome 12.The mechanism of action of SCN8A is to modulate neuronal excitability through the formation of a voltage-gated sodium channel, which is essential for the fast depolarisation of the action potential phase of the action potential is critical. The activity of this channel directly affects the speed and efficiency of neural signalling. Biologically, the normal function of SCN8A is essential for maintaining the normal functioning of the nervous system, and its mutation or abnormal function is associated with a range of neurological disorders, such as epilepsy. Therefore, the gene and protein of SCN8A are important targets for the study and treatment of neurological diseases.

Popular Product:

SCN8A Antibody

Validated Data

WB

Western blot
All lanes: SCN8A antibody IgG at 1.18μg/ml + Rat heart tissue
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 226, 227, 146, 221 kDa
Observed band size: 226 kDa

IHC

Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA891989ESR2HU at dilution of 1:100