SEC16A

SEC16A, also known as KIAA0310, SEC16, SEC16L, and p250, is a critical protein associated with the endoplasmic reticulum (ER). It functions as a key component of the Sec16 complex, which defines exit sites on the ER for the transport of secretory proteins to the Golgi apparatus. By acting as a scaffold, SEC16A meticulously regulates the flow of materials from the ER, ensuring proper trafficking and assembly of COPII vesicles. Disruption of SEC16A has been linked to various diseases, particularly chronic pancreatitis, as it impairs the transport of secreted proteins, leading to ER stress and increased susceptibility to illness. Consequently, SEC16A is essential for maintaining normal cellular functions, managing intracellular transport, and preventing related pathological conditions. Its role in both conventional and unconventional secretion pathways further underscores its significance in cellular homeostasis and disease prevention.