SLC31A1

SLC31A1, known as CTR1 and COPT1, is a high-affinity copper transporter that regulates dietary copper absorption in human cells. Functioning as a homotrimer, SLC31A1 is pivotal for copper homeostasis. Variations in its expression are associated with the development of various cancers, including those of the lung, breast, kidney, and colon. SLC31A1's expression levels can indicate patient survival rates and are implicated in both the reduction and increase of tumor incidence, emphasizing its significance in oncogenesis. Furthermore, its expression patterns in the tumor microenvironment's immune cell infiltration suggest potential as a drug resistance biomarker and a new target for cancer therapies.