SLC4A3

SLC4A3, an anion exchanger with 3 cations, is a transmembrane protein encoded by the SLC4A3 gene. It is predominantly expressed in the renal proximal convoluted tubules and intestinal epithelial cells, where it acts as a HCO3-/Cl- exchanger. SLC4A3 helps maintain acid-base and electrolyte balance, regulating blood pH and promoting renal HCO3- reabsorption. Its dysfunction is associated with hereditary nephropathy, hypertension, diabetes, and other diseases, with potential implications for metabolic acidosis and electrolyte disorders affecting renal and cardiovascular health, making SLC4A3 a key target in kidney disease and metabolic research.

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Recombinant Human Anion exchange protein 3 (SLC4A3), partial