SMYD5

SMYD5, encoded by the SMYD5 gene, possesses histone methyltransferase activity and is expressed across diverse cell types. It catalyzes the methylation of histone H3 at lysine 4, influencing chromatin structure and gene expression, and is involved in cell cycle regulation, proliferation, differentiation, and DNA damage response. SMYD5's abnormal expression in tumors may be associated with oncogenesis, positioning it as a potential target for cancer research and treatment.