TAFAZZIN

TAFAZZIN is an acyltransferase found across various species, from humans to experimental animals. It plays a crucial part in gene expression by binding to TEAD transcription factors and impacting cell processes such as proliferation and differentiation. The protein's diverse domains, characterized by unique amino acid sequences, enable distinct functions: the TEAD binding domain stimulates gene transcription, the WW domain is key in signal transduction, and the PDZ domain ensures proper protein localization within cells. TAFAZZIN is integral to comprehending and addressing the pathogenesis of diseases like cardiomyopathy, endocardial fibroelastosis, and Barth's syndrome, highlighting its importance in medical research, diagnosis, and therapeutic development.