TIR1

TIR1 is recognized as the Transport Inhibition Factor Response Protein 1 and functions as an E3 ubiquitin ligase. It also acts as a receptor for the plant hormone auxin. Found within the plant kingdom and extensively studied in Arabidopsis thaliana, TIR1 detects and binds to AUX/IAA proteins, which are induced by auxin, through its F-box domain. This binding forms the SCF^TIR1 complex, promoting the ubiquitination and degradation of AUX/IAA proteins by the proteasome. As AUX/IAA proteins are degraded, they can no longer inhibit ARF transcription factors, thus activating auxin-responsive genes. TIR1 is pivotal for plant growth, development, and responses to environmental cues. TIR1's activity is modulated by phosphorylation, IAA protein interactions, and crosstalk with other signaling molecules, making it a key player in the signaling pathway.

Popular Product:

Recombinant Arabidopsis thaliana Protein TRANSPORT INHIBITOR RESPONSE 1 (TIR1), partial