TRIM55

TRIM55 is a member of the TRIM protein family. As an E3 ubiquitin ligase, TRIM55 shuttles between the nucleus and cytoplasm, playing a key role in regulating various cellular processes. It promotes the ubiquitination of substrate proteins by specifically recognizing them, thereby controlling their stability, localization, and function. TRIM55 is particularly important in tissues such as the heart and liver, where it is closely linked to conditions like myocardial hypertrophy, tumor growth, and immune regulation. Abnormal expression or dysfunction of TRIM55 can lead to disease, making it a significant focus of biomedical research. Its study holds great promise for uncovering disease mechanisms and developing effective treatment strategies.