TRPM4

TRPM4, also known as transient receptor potential melastatin 4, is a calcium-activated cation channel that plays a crucial role in various physiological processes. It is primarily involved in regulating intracellular calcium signaling, which in turn affects numerous cellular functions such as ion homeostasis, membrane potential, and signal transduction. TRPM4 is expressed in various tissues, including the heart, brain, and immune cells, and its dysregulation is associated with several diseases, including cardiovascular disorders, neurological diseases, and cancers. Research on TRPM4 has identified its involvement in calcium signaling pathways, particularly in the regulation of store-operated calcium entry (SOCE), and its potential as a therapeutic target for various diseases, including cancer and inflammation.