folE

FolE, or dihydrofolate reductase, is an enzyme encoded by the FOLR1 gene, found across bacteria, plants, and animals. It catalyzes the reduction of dihydrofolate to tetrahydrofolate, essential for purine and pyrimidine synthesis. FolE's activity is regulated by factors like folate availability and cell cycle control, and it is a target for anti-folate drugs like methotrexate, used to treat cancer and immune disorders, highlighting its importance in medical research and drug development.