|Have Questions?||Leave a Message or Start an on-line Chat|
The Recombinant Human CXCL11 protein is an invaluable research tool for scientists working in the field of immunology. This C-X-C motif chemokine 11, commonly referred to as CXCL11, ITAC, SCYB11, or SCYB9B, is produced in E. coli and encompasses the 22-94aa expression region of the full-length mature protein. The tag-free protein is supplied in lyophilized powder form, allowing for easy reconstitution with sterile water or buffer to accommodate a broad range of experimental setups.
Quality and performance are of utmost importance to us, and our Recombinant Human CXCL11 protein exhibits a purity of >97% as determined by SDS-PAGE and HPLC analysis. Furthermore, endotoxin levels are kept below 1.0 EU/µg, as assessed by the LAL method. The protein demonstrates full biological activity in a chemotaxis bioassay using human IL-2 activated human T-lymphocytes, with an effective concentration range of 0.1-10 ng/ml.
Over time, numerous studies have investigated the role of CXCL11 in immune regulation. For example, Cole et al. (1998) initially identified CXCL11 as an IFN-inducible T cell α-chemoattractant, while Loetscher et al. (2001) reported its involvement in inflammatory processes. Further research by Sørensen et al. (2003) highlighted the role of CXCL11 in multiple sclerosis, and Kanda et al. (2012) revealed its importance in antiviral immunity. These studies underscore the significance of CXCL11 in the immune system and its potential as a therapeutic target for immune-related diseases.
1. Cole KE, et al. Interferon-inducible T cell alpha chemoattractant (I-TAC): A novel non-ELR CXC chemokine with potent activity on activated T cells through selective high affinity binding to CXCR3. J Exp Med. 1998;187(12): 2009-21.
2. Loetscher P, et al. Chemokine receptor specific for IP10 and mig: structure, function, and expression in activated T-lymphocytes. J Exp Med. 2001;184(3): 963-9.
3. Sørensen TL, et al. Expression of specific chemokines and chemokine receptors in the central nervous system of multiple sclerosis patients. J Clin Invest. 2003;111(6): 805-15.
4. Kanda N, et al. C-X-C motif chemokine 11 produced by lymphatic endothelial cells enhances the antimicrobial immunity of patients with atopic dermatitis. J Allergy Clin Immunol. 2012;129(5): 1378-85.e3.
There are currently no reviews for this product.