Heat shock 70 kDa Antibody

Code CSB-PA362326ZA01CH
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Product Details

Full Product Name
Rabbit anti-Gallus gallus (Chicken) Heat shock 70 kDa protein,partial Polyclonal antibody
Uniprot No.
Target Names
Heat shock 70 kDa protein,partial
Alternative Names
Heat shock 70 kDa protein (HSP70)
Raised in
Rabbit
Species Reactivity
Gallus gallus
Immunogen
Recombinant Gallus gallus Heat shock 70 kDa protein
Immunogen Species
Gallus gallus (Chicken)
Conjugate
Non-conjugate
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB (ensure identification of antigen)
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (12-14 weeks)

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Target Background

Function
Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release.
Gene References into Functions
  1. data indicate that HSP70 is part of the receptor complex of Avian infectious bronchitis virus (IBV) and might help to understand the mechanism of S-mediated cell entry of IBV PMID: 28224252
  2. variation in chicken HSP70 was abundant between and within species PMID: 25867297
  3. The effects of transport time on HSP70 expression, stress, and meat quality are reported. PMID: 25403192
  4. Mn had a dosage-dependent effect on HSP27, HSP40, HSP60, HSP70, and HSP90 mRNA expression in chicken spleen lymphocytes in vitro. PMID: 24081778
  5. Results of this study indicated a long-term enhancement of Hsp70 gene expression associated with improved thermotolerance acquisition in treated chicks without adversely affecting performance. PMID: 23787299
  6. It was concluded that dietary supplementation of Z. officinale and Z. zerumbet powder may induce HSP70 reaction in broiler chickens exposed to heat stress. PMID: 22533311
  7. Data suggest that the expression of HSP70 is heat inducible and tissue dependent and that heat induction may correlate with DNA methylation pattern in the HSP70 promoter. PMID: 23546965
  8. The effects of human interaction on HSP70 expression and stress hormone blood leves in female broiler chickens are reported. PMID: 23243228
  9. It appears that neonatal feed restriction can enhance resistance to Salmonella enteritidis colonization in heat-stressed broiler chicks, and the underlying mechanism could be associated with the lower expression of Hsp70. PMID: 22252346
  10. HSP 70 level increased both in vivo and in vitro trials and may be used as potential molecular and toxicological biomarker. PMID: 19826909
  11. Spinal cord overexpression of Hsp70 enhances motor neuron survival in vivo during the period of naturally occurring cell death. PMID: 16237177
  12. A study evaluating the relationship between tissue or allele and the expression of chicken hsp70 under normal growth conditions and during acute heat stress is reported. PMID: 16905471
  13. The interaction of Meq and Hsp70 is significant in Marek's disease virus oncogenesis. PMID: 19494050
  14. The results suggest that the improved tolerance to transport stress in chicks could be associated with better HSP 70 expression. PMID: 19531704

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Protein Families
Heat shock protein 70 family
Database Links
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