Recombinant Mouse Beta-nerve growth factor(Ngf),partial

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Code CSB-AP004081MO
Product Type Growth Factor
Size $65Purchase it in Cusabio online store
(only available for customers from the US)
Uniprot No. P01139
Image
  • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Storage Buffer Lyophilized from a 0.2 μm Filtered 20 mM Tris-HCl, 200 mM NaCl, pH 8.0
Alias Beta-Nerve Growth Factor; Beta-NGF; NGF; NGFB
Species Mus musculus (Mouse)
Biological_Activity The ED50 as determined in a cell proliferation assay using TF?1 human erythroleukemic cells is less than 5 ng/ml.
Purity Greater than 95% as determined by SDS-PAGE.
Endotoxin Less than 1.0 EU/μg as determined by LAL method.
Sequence MGEFSVCDSVSVWVGDKTTATDIKGKEVTVLAEVNINNSVFRQYFFETKCRASNPVESGCRGIDSKHWNSYCTTTHTFVKALTTDEKQAAWRFIRIDTACVCVLSRKATR
Research Area Neuroscience
Source E.coli
Gene Names Ngf
Expression Region 130-239aa
Tag Info Tag-Free
Mol. Weight 12.4 kDa
Protein Description Partial
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Function Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades through those receptor tyrosine kinase to regulate neuronal proliferation, differentiation and survival. Inhibits metalloproteinase dependent proteolysis of platelet glycoprotein VI.
Subcellular Location Secreted
Protein Families NGF-beta family
Database Links

KEGG: mmu:18049

STRING: 10090.ENSMUSP00000102538

UniGene: Mm.1259

Pathway MAPK signaling pathway
PI3K-Akt signaling pathway
Apoptosis
Ras signaling pathway
Rap1 signaling pathway
Inflammatory Pain
Inhibitors of axonal regeneration

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