MAP2K2 Antibody

Code CSB-PA030302
Size US$100
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  • Western blot analysis of mouse-lung KB 293T lysis using MEK-2 antibody.
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Product Details

Uniprot No.
Target Names
MAP2K2
Alternative Names
Cardiofaciocutaneous syndrome antibody; CFC syndrome antibody; CFC4 antibody; Dual specificity mitogen activated protein kinase kinase 2 antibody; Dual specificity mitogen-activated protein kinase kinase 2 antibody; ERK activator kinase 2 antibody; FLJ26075 antibody; MAP kinase kinase 2 antibody; map2k2 antibody; MAPK / ERK kinase 2 antibody; MAPK/ERK kinase 2 antibody; MAPKK 2 antibody; MAPKK2 antibody; MEK 2 antibody; MEK2 antibody; Microtubule associated protein kinase kinase 2 antibody; Mitogen activated protein kinase kinase 2 antibody; Mitogen activated protein kinase kinase 2 p45 antibody; MKK 2 antibody; MKK2 antibody; MP2K2_HUMAN antibody; OTTHUMP00000165826 antibody; OTTHUMP00000165827 antibody; PRKMK 2 antibody; PRKMK2 antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Synthesized peptide derived from Human MEK-2 around the non-phosphorylation site of T394.
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form
Liquid
Tested Applications
WB, IHC, IP, ELISA
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
IHC 1:100-1:300
IP 2-5ug
ELISA 1:10000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases. Activates BRAF in a KSR1 or KSR2-dependent manner; by binding to KSR1 or KSR2 releases the inhibitory intramolecular interaction between KSR1 or KSR2 protein kinase and N-terminal domains which promotes KSR1 or KSR2-BRAF dimerization and BRAF activation.
Gene References into Functions
  1. Data show that SAM and SH3 domain containing 1 protein (SASH1) binds with mitogen-activated protein kinase kinase 2 (MAP2K2), and SASH1 mutations promote binding between SASH1 and MAP2K2. PMID: 28382689
  2. findings demonstrate the interaction of tRNA with MEK2 in pancreatic cancer cells and suggest that tRNA may impact MEK2 activity in cancer cells PMID: 27301426
  3. MEK2 was essential for the phosphorylation of MKK3/MKK6 and p38 MAPK that directly impacted on cyclin D1 expression. PMID: 27181679
  4. High MEK2 expression is associated with inflammation. PMID: 28178421
  5. there were significant decreases in intercellular adhesion molecules 1 (ICAM1), ezrin (EZR), mitogen-activated protein kinase kinase 2 (MAP2K2), and nitric oxide synthase 3 (NOS3) gene expressions in metabolic syndrome patients. PMID: 26956845
  6. The patient showed a paternally inherited 16p13.11 microduplication and a de novo 19p13.3 microdeletion involving the mitogen-activated protein kinase kinase 2 gene (MAP2K2), in which mutations cause the cardio-facio-cutaneous (CFC) syndrome PMID: 27751966
  7. We report on a fourth familial case with transmission of CFC syndrome from father to son due to a novel heterozygous sequence change c.376A>G (p.N126D) in exon 3 of MEK2 gene. PMID: 25487361
  8. MK2 attenuates dendritic cell-mediated Th1 differentiation and autoimmune encephalomyelitis. PMID: 26078274
  9. Our cohort of seven individuals with MEK2 deletions has overlapping features associated with RASopathies. PMID: 23379592
  10. Both ACE inhibition and MEK1/2 inhibition have beneficial effects on left ventricular function in Lmna(H222P/H222P) mice and both drugs together have a synergistic benefit when initiated after the onset of left ventricular dysfunction. PMID: 25218145
  11. we report familial patients with multiple cafe au lait spots and Noonan syndrome-like facial features who carried mutations in MAP2K2. PMID: 24311457
  12. osteosarcoma patients whose tumors expressed pMEK2 had a poorer clinical outcome than those whose tumors did not. PMID: 22935974
  13. MEK2 regulates ribonucleotide reductase activity through functional interaction with ribonucleotide reductase small subunit p53R2. PMID: 22895183
  14. E-cadherin is necessary for localization of DLG1 but not phosphorylated MEK2 to the midbody ring during cytokinesis. PMID: 22185284
  15. Mycobacterium tuberculosis lipomannan blocks TNF biosynthesis by regulating macrophage MAPK-activated protein kinase 2 (MK2) and microRNA miR-125b. PMID: 21969554
  16. hDlg acts as a MEK2-specific scaffold protein for the ERK signaling pathway. PMID: 21615688
  17. Data report the full-length structure of MEK2 obtained by homology modeling and molecular dynamics simulations. PMID: 21509657
  18. In the absence of other MKK, MEK2 is sufficient for SK-MEL-28 cell proliferation and anchorage-dependent growth. PMID: 21365009
  19. ETS1 is probably mediating high CIP2A expression in human cancers with increased EGFR-MEK1/2-ERK pathway activity PMID: 21445343
  20. familial inheritance of cardiofaciocutaneous syndrome with MEK2 mutation PMID: 21178588
  21. MEK1 and MEK2 play a part in the induction of the proinflammatory cytokine. PMID: 20837746
  22. This first reported case of a vertically transmitted functional Cardio-facio-cutaneous syndrome MEK mutation. PMID: 20358587
  23. MEK2 activity ad dual-phosphorylation were undetectable in expanding and self-renewing hematopoietic progenitors (HP). Adding IL-3, inducing maturation and cell death in HP, led to sustained high levels of MEK2 activity and dual-phosphorylation. PMID: 12032872
  24. MK2 phosphorylates TSC2, which creates a 14-3-3 binding site and thus regulates the cellular function of the TSC2 tumor suppressor protein PMID: 12582162
  25. MAPK activated protein kinase-2 mediates both ERK- and p38 MAPK-dependent neutrophil responses. PMID: 14499342
  26. HuR and MK2 in regulating the expression of uPA and uPAR genes at the posttranscriptional level PMID: 14517288
  27. Results suggest a physiological link between beta-dystroglycan and mitogen-activated protein kinase kinase 2 (MEK2), and localize MEK with dystroglycan in membrane ruffles. PMID: 15071496
  28. The ability of constitutively-active human MEK2 to stimulate ERK phosphorylation and to induce the neoplastic transformation of NIH 3T3 cells required the integrity of the D-site was found. PMID: 15979847
  29. These data suggest a role for mitochondrially generated reactive oxygen species and Ca(2+) in the redox cell signaling path-ways, leading to ERK activation and adaptation of the pathological stress mediated by oxidized lipids such as lysoPC. PMID: 16651638
  30. 3 novel mutations for MEK2 (L46_E55del, K61T, A62P) were identified in 15 patients with cardio-facio-cutaneous syndrome. PMID: 17704260
  31. Spectrum of MEK2 gene mutations in cardio-facio-cutaneous syndrome and genotype-phenotype correlations PMID: 19156172
  32. MEK2 interacts with ERK1. This interaction is mediated via a conserved N-terminal docking site in MEK2. PMID: 11134045

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Involvement in disease
Cardiofaciocutaneous syndrome 4 (CFC4)
Subcellular Location
Cytoplasm. Membrane; Peripheral membrane protein.
Protein Families
Protein kinase superfamily, STE Ser/Thr protein kinase family, MAP kinase kinase subfamily
Database Links

HGNC: 6842

OMIM: 601263

KEGG: hsa:5605

STRING: 9606.ENSP00000262948

UniGene: Hs.465627

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