Recombinant Mouse Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Pik3cd), partial

1. RUNX1 promoted TGF-beta-induced partial EMT by increasing transcription of the PI3K subunit p110delta, which mediated Akt activation. PMID: 29759484
2. As chronic lymphocytic leukemia (CLL) proliferation and survival depends on the microenvironment, we used murine models to assess the efficacy of the BTK inhibitor acalabrutinib combined with the PI3Kdelta inhibitor ACP-319 in vivo.The combination of acalabrutinib and ACP-319 was superior to single-agent treatment in a murine CLL model PMID: 28645939
3. These data showed that p110delta PI3K plays a main role in promoting neointimal thickening and inflammatory processes during vascular stenosis, with its inhibition providing significant reduction in restenosis following carotid injury. PMID: 28851839
4. The data provide the first in vivo evidence that p110delta may play an important role in placental vascularization through manipulating trophoblast giant cell. PMID: 27306493
5. Phosphatidylinositol-3-kinases (PI3K) gamma and delta are key regulators of T cell signaling. Here the author show, using mouse heart allograft transplantation models, that PI3Kgamma or PI3Kdelta deficiency prolongs graft survival, but selective inhibition of PI3Kgamma or PI3Kdelta reveals alternative transplant survival outcomes post CTLA4-Ig treatment. PMID: 29038423
6. High PI3KD expression is associated with chronic lymphocytic leukemia. PMID: 27843137
7. study illustrates the significance of p110delta signaling in LPS-mediated inflammation and demonstrates the importance of this pathway for survival from endotoxic shock PMID: 28659355
8. this study shows that PI3Kdelta regulates Dectin-2 signaling and its dendritic cell function PMID: 27194783
9. increased levels of eosinophils and IgE in p110gamma/delta-/- mice do not abolish the protective effect of p110gamma/delta-deficiency against OVAlbumin-induced allergic airway inflammation. PMID: 27442134
10. PI3Kdelta or Bruton's tyrosine kinase inhibitors increase genomic instability in normal and neoplastic B cells by an AID-dependent mechanism; this effect should be carefully considered, as such inhibitors can be administered to patients for years PMID: 28199309
11. biased CD4(+) T cell differentiation was independent of any crosstalk between CD4(+) T cells and dendritic cells and was mediated via direct exposure of CD4(+) T cells to palmitate, leading to increased activation of a PI3K p110delta-Akt-dependent pathway upon priming. PMID: 28190771
12. p110delta plays an important role in acute but not in chronic inflammation, the latter being included in the early characteristics of atherosclerosis, which might explain the finding that p110delta deficiency fails to inhibit early atherosclerosis. PMID: 25964052
13. Genetic full-body reduction of p110beta in Fmr1 knockout mice normalizes excessive PI3K activity, restores stimulus-induced protein synthesis, and corrects increased dendritic spine density and behavior. PMID: 25921527
14. The findings identify PI3Kdelta as a key regulator of CD8(+) T cell responses that integrates extrinsic cues, including those from other responding cells, to determine the collective behavior of CD8(+) T cell populations responding to infection. PMID: 26311905
15. p110[gamma] but not p110[delta]-specific inhibitor ameliorates renal ischemia-reperfusion injury by reducing necrosis and immune cell migration PMID: 26431158
16. interference with p110delta activity led to reduced surface-expressed TNF in WT but not RP105(-/-) macrophages, while leaving TNF mRNA and protein expression unaffected. PMID: 26371254
17. PI3K signaling must be tightly regulated in lymphocytes as excessive PI3K can lead to autoimmunity, immunodeficiency or cancer, whilst diminished signaling can result in developmental defects and immunodeficiency. (Review) PMID: 26324350
18. A crystal structure of idelalisib bound to the mouse p110delta subunit of PI3Kdelta. PMID: 25631052
19. Data indicate that PI3-kinase subunit delta (PI3Kdelta) is a promising target for systemic lupus erythematosus (SLE). PMID: 24935930
20. p110delta inactivation in regulatory T cells unleashes CD8(+) cytotoxic T cells and induces tumour regression. PMID: 24919154
21. the PI3K subunit p110delta controls homeostatic APC-T cell interactions by altering the balance between IL-10 and IL-12/23. PMID: 24634494
22. the p110delta isoform of the PI3K catalytic subunit is a key component of the PI3K pathway for both FSH and E2-stimulated follicle growth in ovarian granulosa cells. PMID: 23820902
23. Mice lacking functional PI3Kdelta or PI3Kgamma are largely protected from experimentally induced psoriatic dermatitis and correlate with reduced interleukin (IL)-17 levels in lesions, serum, and draining lymph nodes. PMID: 23024273
24. Cytotoxic T lymphocytes -mediated tumor surveillance is severely impaired in the absence of PI3Kdelta. PMID: 22808277
25. By controlling the 'topology' of TLR4 signaling complexes, p110delta balances overall homeostasis in the TLR4 pathway. PMID: 23023391
26. agents targeting p110delta PI3K need not achieve full blockade of the enzyme to be of great benefit in the treatment of Systemic lupus erythematosus (SLE). PMID: 22537464
27. Data suggest that targeting phosphoinositol-3-kinase p110delta activity might be a viable strategy for the treatment of heart chronic rejection. PMID: 22479345
28. PI3K p110delta mediates bone marrow-derived eosinophil trafficking and migration by regulating adhesion molecule expression and localization/distribution as well as promoting changes in cell morphology that favor recruitment during inflammation. PMID: 22427531
29. p110delta-dependent translocation of exogenous CSF-1 to the nucleus-associated CSF-1Rs, correlating with a prominent role of p110delta in activation of the Rab5 GTPase, a key regulator of endocytic trafficking PMID: 22084313
30. Dynamics of the phosphoinositide 3-kinase p110delta interaction with p85alpha and membranes reveals aspects of regulation distinct from p110alpha PMID: 21827948
31. The impaired Treg function in p110delta(D910A) mice can in part be explained by the failure of CD38(high) cells to develop. PMID: 21390257
32. study concludes PI3Kdelta was essential to increased vascular contractile response in model of type I diabetes; PI3Kdelta signalling was up-regulated and most likely accounted for increased Ca(V) 1.2 current leading to increased vascular contractility PMID: 20942845
33. Either p110alpha or p110delta can mediate tonic signaling from the B cell receptor, but only p110delta can contribute to antigen-dependent activation of B cells. PMID: 20699475
34. the magnitude of the germinal cell reaction is controlled by the activity of the PI3K pathway in T follicular helper cells. PMID: 20826752
35. These findings demonstrate a new function for p110delta as part of the membrane fission machinery required at the trans-Golgi network for the selective trafficking and secretion of cytokines in macrophages. PMID: 20837769
36. p110delta contributes to B cell development and maintenance, transformation, and proliferation. PMID: 20200404
37. PI3K signaling events control memory T cell subset differentiation, generation, effector function, and recruitment to cutaneous tissues and provide the means of enhancing desired memory T cell subset, response during vaccination, or both. PMID: 20154209
38. Data show Tat enhanced cell proliferation as well as ERK1/2, STAT3, and PI3K/Akt signals by Kaposin A. PMID: 20019835
39. These studies establish that previously activated memory T cells are at least as sensitive to p110delta inhibition as naive T cells and show that mouse models accurately predict p110delta function in human T cells. PMID: 20081091
40. antigen receptor signaling in B and T cells was impaired and immune responses in vivo were attenuated in p110delta mutant mice; they also developed inflammatory bowel disease; results reveal a selective role for p110delta in immunity PMID: 12130661
41. Results define a nonredundant signaling pathway(s) utilizing the delta isoform of p110 phosphoinositide 3-kinases (PI3K) for the development and function of B cells. PMID: 12446777
42. PI3K delta plays an essential role in certain signaling pathways of neutrophil activation PMID: 12927784
43. p110 delta is present in endothelial cells and participates in neutrophil trafficking by modulating the proadhesive state of these cells in response to tumor necrosis factor alpha PMID: 14751923
44. the p110delta subunit of PI3K is involved in the LPS response in B cells and may represent a link between the innate and the adaptive immune system [review] PMID: 15494016
45. genetic or pharmacological inactivation of the p110delta isoform of PI(3)K in mast cells leads to defective SCF-mediated in vitro proliferation, adhesion and migration, and to impaired allergen-IgE-induced degranulation and cytokine release PMID: 15496927
46. study demonstrates a minor role for the p110delta catalytic subunit in mediating platelet activation by the collagen receptor GPVI and integrin alphaIIbeta3 PMID: 16011964
47. class 1 PI3Ks work in concert to protect developing thymocytes from apoptosis PMID: 16304053
48. p110 delta is dispensable for thymic development of Foxp3+ regulatory T (Treg) cells and yet plays a key role in Treg-mediated suppression of CD4+CD25- T cell proliferation and inflammation. PMID: 17082571
49. role for p110delta in the regulation of RAG gene expression and thereby light chainallelic/isotype exclusion. PMID: 17277100
50. p110delta is not required to kill tumour cells, but unexpectedly p110delta mutant mice failed to fully reject transplanted lymphomas. PMID: 17371233

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KEGG: mmu:18707

STRING: 10090.ENSMUSP00000101315

UniGene: Mm.229108