Cellular Senescence and Its MarkersA cell is not only the basic unit of biological structure and function but also of organismal aging. Most cells of an organism go through several stages during their lives: proliferation, differentiation, senescence, and...
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2021 Insights on the CAR-T Cell Therapy: the Most Popular Targets for Solid Tumor!In recent years, immune cell therapy is driving the next-generation treatment for cancer after surgery, drug, and radiotherapy. Undoubtedly, CAR-T therapy is the central component of a host of promising immunotherapy. Cu...
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Lysosomal Enzymes and Lysosomal Storage Disorders (LSDs)When talking to lysosomal enzymes, we have to first describe lysosomes. Lysosomes were first isolated from rat liver cells using cell fractionation techniques by Christian de Duve and his team in 1955. Lysosomes are memb...
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C5AR1: A Potential Molecule of Complement System to Fuel COVID-19 Therapy!With the COVID-19 cases springing up in multiple regions yet again, the prevention and treatment of COVID-19 has become a research priority for academic and pharmaceutical scientists. Extensive clinical data have demonst...
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CCR8: a Specific Marker on Tregs Cells, the Next Promising Candidate for Antitumor Drugs!Accompanied by great success of PD-(L)1, immunotherapy become the next revolution in cancer treatment, but tumor tissue is commonly infiltrated with a large number of immunosuppressive cells, leading to the unsatisfactor...
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Approaches to Determinate Protein ConcentrationAccurate protein quantification is a critical step in most experiments and workflows where proteins are extracted, isolated, and analyzed by biochemical methods. Analyzing the interactions between biological molecules ...
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GFRAL: A Promising Metabolic Target for Improving Obesity and Anorexia/CachexiaGlobally, nearly 400 million people worldwide are obese and 19.3 million patients have been diagnosed of cancer, according to the statistics of World Health Organization. Each year, tens of thousands of people suffer fro...
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How to Properly Reconstitute Lyophilized Proteins?In scientific research, proteins need to be added to the culture system or injected into the animal body in the form of a liquid with a certain concentration. However, many protein products are provided lyophilized to ...
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GCGR: A Regulator of Energy Balance Holds a Potential in Treatment DiabetesWith the increase in the number of diagnosed diabetes, the diabetes drugs market is estimated to grow year by year. The new drugs design over diabetes treatment has soaked up more ink and excited more passion in recent y...
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Cross-reactivity of Antibody: Beneficial or Harmful?SARS-COV-2, which is ravaging around the world, has been the research hotspot since its breakout in late 2019. At the unremitting efforts of scientific researchers, several types of vaccines against SARS-COV-2 were suc...
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