DLL3: A New Molecular Target in CancerOn October 24, 2024, Zai Lab, a biopharmaceutical company based in the U.S. and China, announced at the EORTC-NCI-AACR (ENA) meeting that its ZL-1310, an antibody-drug conjugate (ADC) targeting DLL3, demonstrated signifi...
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What Is Tomato Mosaic VirusTomato mosaic virus (ToMV), first reported in the United States in 1909, is a type of plant virus with worldwide distribution and can cause severe damage to various crops [1]. So exactly what is the tomato mosaic virus? ...
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Does Antibody-dependent Enhancement Occur in SARS-CoV-2 Infection?In 1964, Hawkes et al. demonstrated enhanced infectivity of viruses, including arboviruses, Murray Valley encephalitis virus, West Nile virus (WNV), Japanese encephalitis virus (JEV), and Getah viruses in the presence of...
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The Overview of Cell ViabilityCell-based assays are generic tools for measuring numerous biochemical or cellular functions. Bioassays can study various events including cell proliferation, morphology, migration, apoptosis, genetics, and signal tran...
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What Are Histones: Unraveling Their Critical Roles in Disease PathogenesisHistones are fundamental proteins that play a vital role in the packaging, organization, and regulation of DNA within the nucleus of eukaryotic cells. They form the building blocks of chromatin, the complex structure in ...
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Claudin 18.2, is a 'Dark Horse' in Anti-tumour Therapy?In May, 2020, the world's first CAR-T therapy targeting Claudin 18.2 was approved in the US; in June, 2020, the world's first Claudin 18.2/PD-L1 bispecific antibody preclinical data was presented at the AACR; and on July...
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GPC3: The Next-Promising Target in Cancer ImmunotherapyRecently, 2021 American Society of Clinical Oncology (ASCO) Annual Meeting announced the abstract of a fourth generation of GPC3 CAR-T (4G-CAR-GPC3 T) cells therapy. The abstract suggested that 4G-CAR-GPC3 T cells treatm...
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Neuronal Markers and Neurodegenerative DiseasesNeurons are highly specialized nerve cells that receive and transmit electrical or chemical signals to coordinate all of the necessary functions for life. Neurons are typically composed of a cell body, dendrites, an ax...
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Oncogenes and CancerIn fact, everyone has genes that possess the ability to cause cancer. These genes are known as proto-oncogenes, which are expressed to control normal cell processes such as proliferation, differentiation, and apoptosis. ...
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Protein Acetylation: An Important Post-translational Modification in Eukaryotic CellsAs is well-known, post-translational modifications (PTMs) are essential mechanisms for eukaryotic cells to diversify protein functions and dynamically coordinate signaling networks. Vincent Allfrey and colleagues first...
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