Chemokine Receptor CCR4: the Key Role of CCR4+Treg Cells in Cancer ImmunotherapyOn Jan 17, 2022, Nature Reviews Clinical Oncology (IF: 66.675) published a review entitled "Harnessing cytokines and chemokines for cancer therapy" [1]. In this article, the authors conclude the high potential of targeti...
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IGFL1: A Novel Secretory Protein of IGF-Like Family Presents a High Cancer-Promoting Potential!Cancer Letters presently published a paper entitled "KLF5-induced lncRNA IGFL2-AS1 promotes basal-like breast cancer cell growth and survival by upregulating the expression of IGFL1" [1]. The study suggested that IGFL1 a...
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The Review of Post-translational ModificationsThe human genome comprises between 20,000 and 25,000 protein-encoding genes [1], while the human proteome is estimated at up to 1,000,000 proteins [2]. Why is the human proteome size far larger than the human gene set? I...
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Bispecific Antibody Overview: From Definition to Application2022 seems to be a "blowout" year in the field of bispecific antibody research and development. The number of drugs on the market in less than one year will exceed the sum of the number of bispecific antibody drugs on th...
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CD24: A Key Element in the EXO-CD24 Technique for Combating COVID-19On July 18, 2021, the WHO COVID-19 Database updated Israel's phase II clinical data on EXO-CD24, a new treatment for COVID-19 (Click here to read more). The preliminary results uncovered that the 29 out of 30 patients wi...
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Cellular Senescence and Its MarkersA cell is not only the basic unit of biological structure and function but also of organismal aging. Most cells of an organism go through several stages during their lives: proliferation, differentiation, senescence, and...
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2021 Insights on the CAR-T Cell Therapy: the Most Popular Targets for Solid Tumor!In recent years, immune cell therapy is driving the next-generation treatment for cancer after surgery, drug, and radiotherapy. Undoubtedly, CAR-T therapy is the central component of a host of promising immunotherapy. Cu...
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Lysosomal Enzymes and Lysosomal Storage Disorders (LSDs)When talking to lysosomal enzymes, we have to first describe lysosomes. Lysosomes were first isolated from rat liver cells using cell fractionation techniques by Christian de Duve and his team in 1955. Lysosomes are memb...
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C5AR1: A Potential Molecule of Complement System to Fuel COVID-19 Therapy!With the COVID-19 cases springing up in multiple regions yet again, the prevention and treatment of COVID-19 has become a research priority for academic and pharmaceutical scientists. Extensive clinical data have demonst...
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CCR8: a Specific Marker on Tregs Cells, the Next Promising Candidate for Antitumor Drugs!Accompanied by great success of PD-(L)1, immunotherapy become the next revolution in cancer treatment, but tumor tissue is commonly infiltrated with a large number of immunosuppressive cells, leading to the unsatisfactor...
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