CAR-T Cell Therapy- An Useful Treatment To Cancer
CAR-T Cell Therapy- An Useful Treatment To CancerGenerally speaking, the foundations of cancer treatment were surgery, chemotherapy, and radiation therapy. But over the past several years, immunotherapy, one type of therapies enlists and strengthens the power of a pati...
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LPS/TLR4 Signal Transduction Pathway
LPS/TLR4 Signal Transduction PathwayIn 1980, Nüsslein-Volhard et al. discovered a gene that determines the dorsal-ventral differentiation in the development of Drosophila embryos and named it Toll [1] [2]. Later, similar homologous receptors were found in...
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What Are the Effects of Abnormalities in the ALK Gene
What Are the Effects of Abnormalities in the ALK GeneAnaplastic lymphoma kinase (ALK) is a transmembrane receptor tyrosine kinase of the insulin receptor superfamily. It is highly homologous with leukocyte tyrosine kinase [1]. ALK plays a major role in the develop...
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These Tumor Databases You Have To Know
These Tumor Databases You Have To KnowCurrently, malignant tumor has become one of the causes of death. The incidence of cancer is increasing globally and the age of onset is getting younger. In 2019, the latest data published by A Cancer Journ...
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Toll-like Receptors--The Eye of Innate Immunity
Toll-like Receptors--The Eye of Innate ImmunityToll-like receptors (TLRs) is a type I transmembrane protein, can identify different pathogen associated molecular patterns (PAMPs), belongs to the surface of the pattern recognition receptors (PRRs). Toll-like receptors...
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Chemokine Receptors – One Kind of Powerful Seven Transmembrane Spanning G Protein-coupled Receptor
Chemokine Receptors – One Kind of Powerful Seven Transmembrane Spanning G Protein-coupled ReceptorChemokine receptors are cytokine receptors expressed on the cell surface as 7-transmembrane proteins that interact with a type of cytokine called a chemokine. Recently, the chemokine receptors have come to attract more a...
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SWISS-PROT: When and How to Use It
SWISS-PROT: When and How to Use ItUniversal Protein Resource (UniProt) comprises the Swiss institute of bioinformatics (SIB), the European institute of bioinformatics (EBI) and the protein information resource (PIR). Its main objective is to provide the ...
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The True Face of Tumor Suppressor Gene p53
The True Face of Tumor Suppressor Gene p53p53 is a tumor suppressor gene that is involved in the development of most cancers in humans. The p53 protein is extremely important for inhibiting the development of cancer. Studies have shown that in addition to tumor ...
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How to Choose the Right Secondary Antibody?
How to Choose the Right Secondary Antibody?Generally speaking, a secondary antibody binds with a primary antibody that is directly attached to the target antigen. In this words, we mention two groups of antibody, one is primary antibody and another is secondary a...
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Effects of FSHR on Fertility and Tumors
Effects of FSHR on Fertility and TumorsAs a member of the glycoprotein subfamily of the G protein-coupled receptor superfamily, FSHR participates in signal transduction by binding to ligands. Follicle stimulating hormone (FSH) is a glycoprotein hormone secret...
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