PD-1-- An Important Immune CheckpointProgrammed death-1 (PD-1), also known as CD279, is another important negative costimulatory molecule following the discovery of CTLA4. Its ligand is PD-L1, also known as CD274, which, like PD-1, belongs to the CD28/B7 fa... Detailed information
CD22- What A Powerful Co-receptor of B Cell ReceptorOn April 23, 2019, Autolus Therapeutics announced that the FDA had granted the AUTO3 drug name. Autolus Therapeutics is a clinical biopharmaceutical company that develops the next generation of programmed T cell therapie... Detailed information
Surface Markers of Natural Killer CellsNK cells, also known as natural killer cells, are a type of cytotoxic lymphocyte that is essential for the innate immune system. It was discovered and named in 1975 for its morphological specificity and was developed fro... Detailed information
Homeobox Transcription Factor- NANOGEmbryonic stem cells (ESCs) are stem cells derived from the undifferentiated inner mass cells of a human embryo. Self-renewal and pluripotency are two distinctive characteristics of undifferentiated embryonic stem cells ... Detailed information
How Do You Get Exosomes?Exosomes were originally regarded as cellular metabolic waste. With the discovery of the antigen-presenting exosomes secreted by B lymphocytes involving anti-tumor responses in 1996 [1]and the exchange of genetic materia... Detailed information
CD146, A Powerful Tumor MarkerCD146 is a membrane glycoprotein of a Ca2+-independent cell adhesion molecule that was first identified as a tumor marker because CD146 is highly expressed in melanoma but not in the corresponding normal control group. I... Detailed information
