CD44- A Powerful Bridge Between CellsLast year, one study from Kanazawa University showed new emerging role of osteopontin in HCV-related hepatocellular carcinoma. As the study mentioned, CD44 has been identified as the most common marker for cancer stem ce...
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Dual Role of TNFRSF14 in ImmunologyTumor necrosis factor receptor superfamily member 14 (TNFRSF14) is a member of the TNF receptor superfamily, also known as herpesvirus entry mediator (HVEM), CD270. In addition, it is also known as another TRAF-related r...
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Does TNF Superfamily Inhibit Cancer or Promote Its Development?The tumor necrosis factor superfamily (TNFSF) consists of 19 ligands and 29 receptors. TNF superfamily members induce a variety of biological effects, including cell growth, differentiation, and death by the interaction ...
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CD19-The Most Popular Target with CAR T-Cell TherapyAs the article named CAR-T Cell Therapy-An Useful Treatment to Cancer mentioned, CAR T-cell therapy is a type of treatment that involves collecting a patient's own immune T-cells and modifying them to produce a chimeric ...
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Tumor Necrosis Factor Receptor Superfamily and ApoptosisTumor necrosis factor receptor superfamily (TNFRSF) belongs to the transmembrane protein receptor, and its characteristic structure is its extracellular domain cysteine-rich domain (CRDs), which usually contains 6 cystei...
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Focus on Emerging Therapeutic Targets BCMATNFRSF17 is a member of the TNF-receptor family and is known as the tumor necrosis factor receptor superfamily member 17, also known as the B cell mature antigen (BCMA or BCM) or CD269, which is a protein encoded by the ...
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IL-6-Do You Really Know That?Interleukin-6, also known as IL-6, is a cytokine that belongs to the class of interleukins. It is produced by fibroblasts, monocytes/macrophages, T lymphocytes, B lymphocytes, epithelial cells, keratinocytes, and various...
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Stem Cell-What a Miraculous Resource in Human BodyWhen comes to stem cells, youth and vitality will emerge in our mind. For this reason, stem cells have always been associated with the topic of longevity. But the definition, type and function of stem cells are often ill...
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Biological Activity of ProteinsProteins were first described by the Dutch chemist Gerardus Johannes Mulder and named by the Swedish chemist Jöns Jacob Berzelius in 1838 [1]. After that, the world of proteins opens up. Proteins, a group of biological ...
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EGFR and Its Application in Cancer Therapy1. Basic Information of EGFR Protein 2. The Structure of EGFR Protein 3. EGFR Protein Signaling Pathway 4. EGFR and Tumor 5. EGFR Antibody D...
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