5HT1A

5HT1A, the serotonin 1A receptor, is a G protein-coupled receptor encoded by human genes and predominantly expressed in the brain, spinal cord, and gastrointestinal tract. Upon binding to 5-hydroxytryptamine (5-HT), it modulates intracellular cAMP levels through G protein signaling, thereby influencing cell function. The 5HT1A receptor is involved in the regulation of mood, sleep, pain perception, and cognitive function, making it a significant target for the development of antidepressants and anxiolytics. Abnormalities in 5HT1A receptor function are linked to mental disorders such as depression, anxiety, and schizophrenia.