AARS2

AARS2 is a crucial protein predominantly active in the mitochondria. AARS2 serves as a key enzyme in the transport of amino acids and the synthesis of proteins. Additionally, it functions as a lactate-sensing protein and lactate transferase. By monitoring L-lactic acid levels, AARS2 modulates the activity of other proteins through lactate modification. Beyond its role in protein synthesis, AARS2 influences the innate immune system, impacting viral infection and immune evasion. Dysregulation of AARS2 is linked to various types of cancer and may contribute to oncogenic processes. Furthermore, AARS2 has potential as a biomarker for assessing prognosis and response to immunotherapy.