Neuronal receptor tyrosine kinase that is essentially and transiently expressed in specific regions of the central and peripheral nervous systems and plays an important role in the genesis and differentiation of the nervous system. Transduces signals from ligands at the cell surface, through specific activation of the mitogen-activated protein kinase (MAPK) pathway. Phosphorylates almost exclusively at the first tyrosine of the Y-x-x-x-Y-Y motif. Following activation by ligand, ALK induces tyrosine phosphorylation of CBL, FRS2, IRS1 and SHC1, as well as of the MAP kinases MAPK1/ERK2 and MAPK3/ERK1. Acts as a receptor for ligands pleiotrophin (PTN), a secreted growth factor, and midkine (MDK), a PTN-related factor, thus participating in PTN and MDK signal transduction. PTN-binding induces MAPK pathway activation, which is important for the anti-apoptotic signaling of PTN and regulation of cell proliferation.
The following ALK reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
ALK Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA209313 | Phospho-ALK (Tyr1507) Antibody |
Human,Mouse | ELISA,WB |
CSB-PA116393 | Phospho-ALK (Tyr1096) Antibody |
Human,Mouse | ELISA,IHC |
CSB-PA045830 | ALK Antibody |
Human | ELISA,IHC,IF |
CSB-PA154906 | Phospho-ALK (Tyr1604) Antibody |
Human | ELISA,WB,IHC,IF |
CSB-PA008445 | Phospho-ALK (Y1507) Antibody |
Human,Mouse,Monkey | WB, IHC, ELISA |
CSB-PA008446 | Phospho-ALK (Y1604) Antibody |
Human | WB, IHC, IF, ELISA |
CSB-PA008448 | Phospho-ALK (Y1096) Antibody |
Human,Mouse | IHC, ELISA |
CSB-PA008450 | ALK Antibody |
Human | WB, IHC, IF, ELISA |
CSB-PA008462 | ALK Antibody |
Human,Mouse | IHC, ELISA |
CSB-PA008463 | ALK Antibody |
Human,Mouse | WB, ELISA |
CSB-PA008468 | ALK Antibody |
Human,Mouse | WB, ELISA |
CSB-PA847171 | ALK Antibody |
Human,Mouse | ELISA,IHC |
CSB-PA21109A0Rb | ALK Antibody |
Human | ELISA, IHC, IF |
ALK Proteins for Mus musculus (Mouse)
Code | Product Name | Source |
---|---|---|
CSB-YP001606MO CSB-EP001606MO CSB-BP001606MO CSB-MP001606MO CSB-EP001606MO-B |
Recombinant Mouse ALK tyrosine kinase receptor (Alk), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ALK Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-YP890938HU CSB-EP890938HU CSB-BP890938HU CSB-MP890938HU CSB-EP890938HU-B |
Recombinant Human ALK tyrosine kinase receptor (ALK), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |