APC

The APC gene encodes the adenomatous polyposis coli protein. It is also commonly known as "the gatekeeper of the colon" due to its crucial role in maintaining normal cell growth. APC functions mainly through regulating the Wnt signaling pathway. By interacting with β - catenin, it promotes its degradation, thereby preventing abnormal cell proliferation.
Mutations in APC are strongly linked to familial adenomatous polyposis (FAP), a hereditary condition that significantly increases the risk of colorectal cancer. In drug development, targeting the APC - related Wnt pathway is a promising area. Some small - molecule inhibitors are under research to correct the dysregulated signaling caused by APC mutations.

Validated Data

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

APC Recombinant Monoclonal Antibody (CSB-RA951649A0HU)

Validated Data

Western Blot
Positive WB detected in: Hela whole cell lysate, K562 whole cell lysate, SH-SY5Y whole cell lysate, A549 whole cell lysate, Rat Brain whole cell lysate
All lanes: APC antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 312, 301, 309 kDa
Observed band size: 160 kDa

IHC image of CSB-RA951649A0HU diluted at 1:100 and staining in paraffin-embedded human breast cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.

The following APC reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

APC Antibodies

APC Proteins

APC Antibodies

APC Antibodies for Homo sapiens (Human)

Code	Product Name	Species Reactivity	Application
CSB-PA000897	APC Antibody	Human,Mouse,Rat	WB, IHC, IF, ELISA
CSB-PA009252	Phospho-APC (S2054) Antibody	Human	WB, IHC, ELISA
CSB-PA009253	APC Antibody	Human	IHC, ELISA
CSB-PA010692	APC Antibody	Human,Mouse,Rat	ELISA,IHC
CSB-PA589353	APC Antibody	Human,Mouse,Rat	ELISA,IHC
CSB-RA951649A0HU	APC Recombinant Monoclonal Antibody	Human, Rat	ELISA, WB, IHC

APC Proteins

APC Proteins for Rattus norvegicus (Rat)

Code	Product Name	Source
CSB-YP001894RA CSB-EP001894RA CSB-BP001894RA CSB-MP001894RA CSB-EP001894RA-B	Recombinant Rat Adenomatous polyposis coli protein (Apc), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

APC Proteins for Homo sapiens (Human)

Code	Product Name	Source
CSB-YP001894HU CSB-BP001894HU CSB-MP001894HU CSB-EP001894HU-B	Recombinant Human Adenomatous polyposis coli protein (APC), partial	Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP001894HU	Recombinant Human Adenomatous polyposis coli protein (APC), partial	E.coli

APC Proteins for Mus musculus (Mouse)

Code	Product Name	Source
CSB-YP726744MO CSB-BP726744MO CSB-MP726744MO CSB-EP726744MO-B	Recombinant Mouse Adenomatous polyposis coli protein (Apc), partial	Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

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APC

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