Probable Polycomb group (PcG) protein involved in transcriptional regulation mediated by ligand-bound nuclear hormone receptors, such as retinoic acid receptors (RARs) and peroxisome proliferator-activated receptor gamma (PPARG). Acts as coactivator of RARA and RXRA through association with NCOA1. Acts as corepressor for PPARG and suppresses its adipocyte differentiation-inducing activity (By similarity). Non-catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1). Acts as a sensor of N(6)-methyladenosine methylation on DNA (m6A): recognizes and binds m6A DNA, leading to its ubiquitination and degradation by TRIP12, thereby inactivating the PR-DUB complex and regulating Polycomb silencing.
The following ASXL1 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
ASXL1 Proteins for Mus musculus (Mouse)
Code | Product Name | Source |
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CSB-YP002253MO CSB-EP002253MO CSB-BP002253MO CSB-MP002253MO CSB-EP002253MO-B |
Recombinant Mouse Putative Polycomb group protein ASXL1 (Asxl1), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ASXL1 Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-YP809007HU CSB-EP809007HU CSB-BP809007HU CSB-MP809007HU CSB-EP809007HU-B |
Recombinant Human Putative Polycomb group protein ASXL1 (ASXL1), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |