Serine/threonine-protein kinase ATR is a protein in humans that is encoded by ATR gene. Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates BRCA1, CHEK1, MCM2, RAD17, RPA2, SMC1 and p53/TP53, which collectively inhibit DNA replication and mitosis and promote DNA repair, recombination and apoptosis. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at sites of DNA damage, thereby regulating DNA damage response mechanism. Required for FANCD2 ubiquitination. Critical for maintenance of fragile site stability and efficient regulation of centrosome duplication.
The following ATR reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
ATR Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA002433GA01HU | ATR Antibody |
Human,Mouse,Rat | ELISA,WB |
CSB-PA267100 | ATR (Ab-428) Antibody |
Human | ELISA,IHC |
CSB-PA058282 | Phospho-ATR (Ser428) Antibody |
Human | ELISA,IHC |
CSB-PA030127 | Phospho-ATR (S428) Antibody |
Human | IHC, ELISA |
CSB-PA030128 | ATR Antibody |
Human | WB, IHC, ELISA |
CSB-PA622666LA01HU | ATR Antibody |
Human | ELISA, WB, IHC |
CSB-PA622666LD01HU | ATR Antibody, Biotin conjugated |
Human | ELISA |
ATR Antibodies for Arabidopsis thaliana (Mouse-ear cress)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA863791XA01DOA | ATR Antibody |
Arabidopsis thaliana | ELISA, WB (ensure identification of antigen) |
ATR Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-YP622666HU CSB-EP622666HU CSB-BP622666HU CSB-MP622666HU CSB-EP622666HU-B |
Recombinant Human Serine/threonine-protein kinase ATR (ATR), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ATR Proteins for Arabidopsis thaliana (Mouse-ear cress)
Code | Product Name | Source |
---|---|---|
CSB-YP863791DOA CSB-EP863791DOA CSB-BP863791DOA CSB-MP863791DOA CSB-EP863791DOA-B |
Recombinant Arabidopsis thaliana Serine/threonine-protein kinase ATR (ATR), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ATR Proteins for Xenopus laevis (African clawed frog)
Code | Product Name | Source |
---|---|---|
CSB-YP872068XBE CSB-EP872068XBE CSB-BP872068XBE CSB-MP872068XBE CSB-EP872068XBE-B |
Recombinant Xenopus laevis Serine/threonine-protein kinase atr (atr), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
ATR Proteins for Mus musculus (Mouse)
Code | Product Name | Source |
---|---|---|
CSB-YP872870MO CSB-EP872870MO CSB-BP872870MO CSB-MP872870MO CSB-EP872870MO-B |
Recombinant Mouse Serine/threonine-protein kinase ATR (Atr), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |