Serine/threonine-protein kinase ATR is a protein in humans that is encoded by ATR gene. Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates BRCA1, CHEK1, MCM2, RAD17, RPA2, SMC1 and p53/TP53, which collectively inhibit DNA replication and mitosis and promote DNA repair, recombination and apoptosis. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at sites of DNA damage, thereby regulating DNA damage response mechanism. Required for FANCD2 ubiquitination. Critical for maintenance of fragile site stability and efficient regulation of centrosome duplication.

ATR Antibodies

ATR Antibodies for Homo sapiens (Human)

ATR Antibodies for Arabidopsis thaliana (Mouse-ear cress)

ATR Proteins

ATR Proteins for Homo sapiens (Human)

ATR Proteins for Arabidopsis thaliana (Mouse-ear cress)

ATR Proteins for Xenopus laevis (African clawed frog)

ATR Proteins for Mus musculus (Mouse)


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