BET1

BET1, Bet1 Golgi vesicle membrane transport protein, alias HBET1.BET1 is a protein encoded in humans that belongs to the class of Golgi-associated membrane proteins involved in vesicular transport from the endoplasmic reticulum (ER) to the Golgi complex.The BET1 protein functions as a soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE), which may involve docking of ER-derived vesicles to cis-Golgi membranes and is essential for proper protein folding, modification, and transport. The gene has multiple transcript variants, generated by variable splicing.

The biological significance of BET1 is mainly in its role in the regulation of intracellular protein transport and metabolic processes. It is expressed in a variety of tissues, especially in the placenta and adrenal gland, etc. Abnormal function of BET1 has been associated with certain diseases, such as neonatal-onset type II citrullinemia (Type Ii, Neonatal-Onset) and neonatal intrahepatic cholestasis due to citric acid deficiency (NICCD, Neonatal Intrahepatic Cholestasis). Neonatal Intrahepatic Cholestasis Due To Citrin Deficiency).The activity and regulatory mechanisms of BET1 are essential for maintaining the stability of the intracellular environment and interorganelle communication.