BRCA1, breast cancer susceptibility gene 1. also known as FANCS, PSCP, it is encoded by the human BRCA1 gene, which is located at position q21 on chromosome 17.
BRCA1 is a nucleophosmin that functions as a tumor suppressor and is involved in a variety of cellular processes, including transcription, repair of DNA double-strand breaks, and recombination. The mechanism of action of BRCA1 involves interaction with a multiple proteins to form the BRCA1-associated genome-monitoring complex (BASC), which is involved in DNA damage repair and cell cycle regulation. The BRCA1-BARD1 heterodimer exhibits E3Ub ligase activity, which is involved in DNA end resection and DNA protection.
BRCA1 is essential for the maintenance of genome stability, and mutations in it can lead to hereditary breast and ovarian cancers , affecting approximately 40% of hereditary breast cancers and more than 80% of hereditary breast and ovarian cancers.
Validated Data
Western Blot analysis of 293 cells using BRCA1 Polyclonal Antibody
Western Blot analysis of 823 293-UV 22RV1 cells using BRCA1 Polyclonal Antibody
The following BRCA1 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
BRCA1 Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA09659A0Rb | BRCA1 Antibody | Human | ELISA |
CSB-PA09659B0Rb | BRCA1 Antibody, HRP conjugated | Human | ELISA |
CSB-PA09659D0Rb | BRCA1 Antibody, Biotin conjugated | Human | ELISA |
CSB-PA002794GA01HU | BRCA1 Antibody | Human | ELISA,WB,IHC |
CSB-PA596474 | Phospho-BRCA1 (Ser1524) Antibody | Human | ELISA,IHC |
CSB-PA234605 | Phospho-BRCA1 (Ser1423) Antibody | Human | ELISA,WB,IHC |
CSB-PA904513 | BRCA1 (Ab-1524) Antibody | Human | ELISA,WB,IF |
CSB-PA186422 | BRCA1 (Ab-1423) Antibody | Human | ELISA,WB,IHC |
CSB-PA901818 | Phospho-BRCA1 (Ser988) Antibody | Human | ELISA,IF |
CSB-PA258596 | Phospho-BRCA1 (Ser1457) Antibody | Human | ELISA,WB |
CSB-PA001041 | BRCA1 Antibody | Human | WB, IHC, ELISA |
CSB-PA001042 | BRCA1 Antibody | Human,Rat | WB, IHC, IF, ELISA |
CSB-PA050135 | Phospho-BRCA1 (S1423) Antibody | Human,Rat | WB, IHC, ELISA |
CSB-PA050136 | Phospho-BRCA1 (S1524) Antibody | Human | IHC, ELISA |
CSB-PA050137 | Phospho-BRCA1 (S1457) Antibody | Human | WB, ELISA |
CSB-PA050138 | BRCA1 Antibody | Human | WB, ELISA |
CSB-PA050139 | BRCA1 Antibody | Human | IHC, ELISA |
CSB-PA291937 | BRCA1 Antibody | Human | ELISA,IHC |
CSB-PA678542 | BRCA1 Antibody | Human | ELISA,IHC |
BRCA1 Antibodies for Arabidopsis thaliana (Mouse-ear cress)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA844583XA01DOA | BRCA1 Antibody | Arabidopsis thaliana | ELISA, WB (ensure identification of antigen) |
BRCA1 Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-YP002794HU CSB-EP002794HU CSB-BP002794HU CSB-MP002794HU CSB-EP002794HU-B |
Recombinant Human Breast cancer type 1 susceptibility protein (BRCA1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-RP096594h(N) | Recombinant Human Breast cancer type 1 susceptibility protein (BRCA1), partial | E.coli |
BRCA1 Proteins for Mus musculus (Mouse)
Code | Product Name | Source |
---|---|---|
CSB-YP344548MO CSB-EP344548MO CSB-BP344548MO CSB-MP344548MO CSB-EP344548MO-B |
Recombinant Mouse Breast cancer type 1 susceptibility protein homolog (Brca1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
BRCA1 Proteins for Rattus norvegicus (Rat)
Code | Product Name | Source |
---|---|---|
CSB-YP526320RA CSB-EP526320RA CSB-BP526320RA CSB-MP526320RA CSB-EP526320RA-B |
Recombinant Rat Breast cancer type 1 susceptibility protein homolog (Brca1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
BRCA1 Proteins for Macaca mulatta (Rhesus macaque)
Code | Product Name | Source |
---|---|---|
CSB-YP740265MOW CSB-EP740265MOW CSB-BP740265MOW CSB-MP740265MOW CSB-EP740265MOW-B |
Recombinant Macaca mulatta Breast cancer type 1 susceptibility protein homolog (BRCA1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
BRCA1 Proteins for Pongo pygmaeus (Bornean orangutan)
Code | Product Name | Source |
---|---|---|
CSB-YP743602EXP CSB-EP743602EXP CSB-BP743602EXP CSB-MP743602EXP CSB-EP743602EXP-B |
Recombinant Pongo pygmaeus Breast cancer type 1 susceptibility protein homolog (BRCA1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
BRCA1 Proteins for Gorilla gorilla gorilla (Western lowland gorilla)
Code | Product Name | Source |
---|---|---|
CSB-YP753729GGZ CSB-EP753729GGZ CSB-BP753729GGZ CSB-MP753729GGZ CSB-EP753729GGZ-B |
Recombinant Gorilla gorilla gorilla Breast cancer type 1 susceptibility protein homolog (BRCA1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
BRCA1 Proteins for Bos taurus (Bovine)
Code | Product Name | Source |
---|---|---|
CSB-YP769686BO CSB-EP769686BO CSB-BP769686BO CSB-MP769686BO CSB-EP769686BO-B |
Recombinant Bovine Breast cancer type 1 susceptibility protein homolog (BRCA1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
BRCA1 Proteins for Canis lupus familiaris (Dog) (Canis familiaris)
Code | Product Name | Source |
---|---|---|
CSB-YP839156DO CSB-EP839156DO CSB-BP839156DO CSB-MP839156DO CSB-EP839156DO-B |
Recombinant Dog Breast cancer type 1 susceptibility protein homolog (BRCA1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
BRCA1 Proteins for Arabidopsis thaliana (Mouse-ear cress)
Code | Product Name | Source |
---|---|---|
CSB-YP844583DOA CSB-EP844583DOA CSB-BP844583DOA CSB-MP844583DOA CSB-EP844583DOA-B |
Recombinant Arabidopsis thaliana Protein BREAST CANCER SUSCEPTIBILITY 1 homolog (BRCA1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
BRCA1 Proteins for Pan troglodytes (Chimpanzee)
Code | Product Name | Source |
---|---|---|
CSB-YP861936EQV CSB-EP861936EQV CSB-BP861936EQV CSB-MP861936EQV CSB-EP861936EQV-B |
Recombinant Pan troglodytes Breast cancer type 1 susceptibility protein homolog (BRCA1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |