BTK

Tyrosine-protein kinase BTK is a protein in humans that is encoded by BTK gene. Non-receptor tyrosine kinase indispensable for B lymphocyte development, differentiation and signaling. Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation. After BCR engagement and activation at the plasma membrane, phosphorylates PLCG2 at several sites, igniting the downstream signaling pathway through calcium mobilization, followed by activation of the protein kinase C (PKC) family members. PLCG2 phosphorylation is performed in close cooperation with the adapter protein B-cell linker protein BLNK. BTK acts as a platform to bring together a diverse array of signaling proteins and is implicated in cytokine receptor signaling pathways. Plays an important role in the function of immune cells of innate as well as adaptive immunity, as a component of the Toll-like receptors (TLR) pathway. The TLR pathway acts as a primary surveillance system for the detection of pathogens and are crucial to the activation of host defense. Especially, is a critical molecule in regulating TLR9 activation in splenic B-cells. Within the TLR pathway, induces tyrosine phosphorylation of TIRAP which leads to TIRAP degradation. BTK plays also a critical role in transcription regulation. Induces the activity of NF-kappa-B, which is involved in regulating the expression of hundreds of genes. BTK is involved on the signaling pathway linking TLR8 and TLR9 to NF-kappa-B. Transiently phosphorylates transcription factor GTF2I on tyrosine residues in response to BCR. GTF2I then translocates to the nucleus to bind regulatory enhancer elements to modulate gene expression. ARID3A and NFAT are other transcriptional target of BTK. BTK is required for the formation of functional ARID3A DNA-binding complexes. There is however no evidence that BTK itself binds directly to DNA. BTK has a dual role in the regulation of apoptosis.

BTK Antibodies

BTK Antibodies for Homo sapiens (Human)

Code Product Name Species Reactivity Application
CSB-PA002867GA01HU BTK Antibody Human,Mouse,Rat ELISA,WB
CSB-PA142166 Phospho-BTK (Tyr223) Antibody Human,Mouse,Rat ELISA,WB
CSB-PA000638 Phospho-BTK (Y223) Antibody Human,Mouse,Rat WB,ELISA
CSB-PA000639 Phospho-BTK (Y551) Antibody Human,Mouse,Rat WB,ELISA
CSB-PA001066 BTK Antibody Human,Mouse,Rat,Monkey WB,IHC,ELISA
CSB-PA005537 BTK Antibody Human,Mouse,Rat WB,ELISA
CSB-PA002867LA01HU BTK Antibody Human, Mouse ELISA, WB, IHC, IF
CSB-PA002867LB01HU BTK Antibody, HRP conjugated Human ELISA
CSB-PA002867LC01HU BTK Antibody, FITC conjugated Human ELISA
CSB-PA002867LD01HU BTK Antibody, Biotin conjugated Human ELISA

BTK Proteins

BTK Proteins for Mus musculus (Mouse)

Code Product Name Source
CSB-YP002867MO Recombinant Mouse Tyrosine-protein kinase BTK(Btk),Yeast Yeast
CSB-EP002867MO Recombinant Mouse Tyrosine-protein kinase BTK(Btk),Escherichia Coli E.coli
CSB-BP002867MO Recombinant Mouse Tyrosine-protein kinase BTK(Btk),Baculovirus Baculovirus
CSB-MP002867MO Recombinant Mouse Tyrosine-protein kinase BTK(Btk),Mammalian cell Mammalian cell

BTK Proteins for Gallus gallus (Chicken)

Code Product Name Source
CSB-YP814261CH Recombinant Chicken Tyrosine-protein kinase BTK(BTK) ,partial,Yeast Yeast
CSB-EP814261CH Recombinant Chicken Tyrosine-protein kinase BTK(BTK) ,partial,Escherichia Coli E.coli
CSB-BP814261CH Recombinant Chicken Tyrosine-protein kinase BTK(BTK) ,partial,Baculovirus Baculovirus
CSB-MP814261CH Recombinant Chicken Tyrosine-protein kinase BTK(BTK) ,partial,Mammalian cell Mammalian cell

BTK Proteins for Homo sapiens (Human)

Code Product Name Source
CSB-YP002867HU Recombinant Human Tyrosine-protein kinase BTK(Btk) Yeast
CSB-EP002867HU Recombinant Human Tyrosine-protein kinase BTK(Btk),Escherichia Coli E.coli
CSB-BP002867HU Recombinant Human Tyrosine-protein kinase BTK(BTK) Baculovirus
CSB-MP002867HU Recombinant Human Tyrosine-protein kinase BTK(Btk),Mammalian cell Mammalian cell

BTK cDNA

BTK cDNA for Homo sapiens (Human)

Code Product Name Vector Accession NO.
CSB-CL002867HU BTK pUC NM_000061.2

BTK cDNA for Mus musculus (Mouse)

Code Product Name Vector Accession NO.
CSB-CL002867MO Btk pUC NM_013482.2

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