Forms the heterodimeric complex core-binding factor (CBF) with RUNX family proteins (RUNX1, RUNX2, and RUNX3). RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. The heterodimers bind to the core site of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM-CSF promoters. CBF complexes repress ZBTB7B transcription factor during cytotoxic (CD8+) T cell development. They bind to RUNX-binding sequence within the ZBTB7B locus acting as transcriptional silencer and allowing for cytotoxic T cell differentiation.
The following CBFB reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
CBFB Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA004577GA01HU | CBFB Antibody |
Human,Mouse,Rat | ELISA,IHC |
CSB-PA623835ESR1HU | CBFB Antibody |
Human | ELISA, IHC |
CSB-PA107678 | CBFB Antibody |
Human,Mouse,Rat | ELISA,WB,IHC |
CSB-PA003737 | CBFB Antibody |
Human,Mouse,Rat | WB, IHC, IF, ELISA |
CSB-PA623835LA01HU | CBFB Antibody |
Human | ELISA |
CBFB Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-YP623835HU CSB-BP623835HU CSB-MP623835HU CSB-EP623835HU-B |
Recombinant Human Core-binding factor subunit beta (CBFB) |
Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-EP623835HU | Recombinant Human Core-binding factor subunit beta (CBFB) |
E.coli |